翻訳と辞書 Words near each other ・ Nerve block ・ Nerve center ・ Nerve centre ・ Nerve Centre (organisation) ・ Nerve compression syndrome ・ Nerve conduction study ・ Nerve conduction velocity ・ Nerve cord ・ Nerve Damage ・ Nerve Engine ・ Nerve fascicle ・ Nerve fiber ・ Nerve fiber layer ・ Nerve Filter ・ Nerve growth factor ・ Nerve growth factor IB ・ Nerve growth factor receptor ・ Nerve guidance conduit ・ Nerve induction ・ Nerve injury ・ Nerve Net ・ Nerve net ・ Nerve of a covering ・ Nerve of Latarjet ・ Nerve of pterygoid canal ・ Nerve of Wrisberg ・ Nerve plexus ・ Nerve point of neck ・ Nerve root ・ Nerve sheath tumor Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Nerve growth factor IB ： ウィキペディア英語版 Nerve growth factor IB The nerve growth factor IB (NGFIB) also known as Nur77 or NR4A1 (nuclear receptor subfamily 4 group A member 1) is a protein that in humans is encoded by the ''NR4A1'' gene.〔〔 Nerve growth factor IB is a member of the ''Nur'' nuclear receptor family of intracellular transcription factors. NGFIB is involved in cell cycle mediation, inflammation and apoptosis.〔 The NGFIB protein plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NGFIB protein appears to play a key role in the survival and death of cells. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3164 )〕 ==Structure== The ''NR4A1'' gene contains seven exons. An amino terminal transactivation domain is encoded in exon 2, a DNA-binding domain in exons 3 and 4, and dimerisation and ligand-binding domains is exons 5 to 7.〔 The protein has an atypical ligand-binding domain that is unlike the classical ligand-binding domain in most nuclear receptors. The classical domain contains a ligand-receiving pocket and co-activator site, both of which are lacking in the NR4A family. Where most nuclear receptors have a hydrophobic surface that results in a cleft, NGFI-B has a hydrophilic surface.〔 Cofactors interact with NGFI-B at a hydrophobic region between helices 11 and 12 to modulate transcription.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Nerve growth factor IB」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.